What are the cardiac consequences of COVID-19 infection in children?

Bottom Line:

Children may develop heart failure due to a severe inflammatory state caused by SARS-CoV-2 infection called multisystem inflammatory syndrome in children (MIS-C).


Belhadjer, Z. et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation (2020). https://doi.org/10.1161/CIRCULATIONAHA.120.048360

Date Published:

17 May 2020


Typically, pediatric COVID-19 patients are minimally symptomatic. However, this study highlights 35 children (2-16 years old) who experienced acute heart failure that may be associated with COVID-19. The researchers postulate that this cardiac consequence was caused by multisystem inflammatory syndrome in children (MIS-C), a complication of COVID-19 that may occur due to severe inflammation. Treatment with immune globulin was associated with improvement in heart function. In addition, all the pediatric patients survived and recovered.

Summary by: Jackie Tsang