What is the prevalence of asthma in patients who are not hospitalized with the SARS-CoV-2 infection?

Bottom Line: Few non-hospitalized patients infected with SARS-CoV-2 presented with asthma. Furthermore, the infection has not been found to be a significant contributor to asthma exacerbation. Reference: Garcia-Pachon E. et al. Asthma prevalence in patients with SARS-CoV-2 infection detected by RT-PCR not requiring hospitalization. Respir Med (2020). DOI: 10.1016/j.rmed.2020.106084 Date Published: 4 July 2020 Synopsis: … Continue reading What is the prevalence of asthma in patients who are not hospitalized with the SARS-CoV-2 infection?

What proportion of the population of Spain has developed antibodies to the SARS-CoV-2 infection?

Bottom Line: Only approximately 5% of the Spanish population has developed antibodies to SARS-CoV-2 after the initial epidemic wave. Reference: Pollán, M. et al. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. The Lancet (2020). https://doi.org/10.1016/s0140-6736(20)31483-5 Date Published: 6 July 2020 Synopsis: Spain was one of the European countries most affected by the … Continue reading What proportion of the population of Spain has developed antibodies to the SARS-CoV-2 infection?

Can public health campaigns help change behaviours that lead to reduced COVID-19 transmission?

Bottom Line: A public health campaign in the Netherlands using a widely-circulated news article with infographics and a video featuring a social media influencer led to increases in hand washing, greater awareness of face touching, and physical distancing. Reference: Yousuf, H. et al. Association of a public health campaign about coronavirus disease 2019 promoted by news … Continue reading Can public health campaigns help change behaviours that lead to reduced COVID-19 transmission?

How is the SARS-CoV-2 virus able to invade the brain and cause an infection?

Bottom Line: The slightly positively charged spike protein is thought to allow the virus to enter the central nervous system and cause a brain infection. Reference: Hassanzadeh, K. et al. Considerations around the SARS-Cov-2 spike protein with particular attention to COVID-19 brain infection and neurological symptoms. ACS Chemical Neuroscience (2020). https://doi.org/10.1021/acschemneuro.0c00373 Date Published: 6 July 2020 Synopsis: Increasing … Continue reading How is the SARS-CoV-2 virus able to invade the brain and cause an infection?

During the COVID-19 pandemic, have there been more deaths of any cause than would have been expected based on the death rate in previous years?

Bottom Line: From March 1 through to May 30, 2020 there were 120,000 more deaths than would have been expected based on previous years, with roughly 80% of these extra deaths being due to COVID-19 and 20% being due to causes other than COVID-19. Reference: Weinberger, D.M. et al. Estimation of excess deaths associated with the … Continue reading During the COVID-19 pandemic, have there been more deaths of any cause than would have been expected based on the death rate in previous years?

What clinical characteristics of patients with cancer are associated with worse COVID-19 disease?

Bottom Line: Older age and medications called immune checkpoint inhibitors are associated with more severe COVID-19 infections in patients with cancer. Reference: Robilotti, E.V. et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med (2020). https://doi.org/10.1038/s41591-020-0979-0 Date Published: 24 June 2020 Synopsis: Previous studies have shown that patients with cancer have a higher risk of death … Continue reading What clinical characteristics of patients with cancer are associated with worse COVID-19 disease?

How did adolescents view COVID-19 at the start of the pandemic, and how did their attitudes shape their associated behaviors?

Bottom Line: The majority of adolescents did not practice physical distancing, but did practice disinfecting behaviors and followed COVID-related news. Those who viewed the virus as more severe were significantly more likely to follow the news, practice physical distancing, and disinfecting behaviors. Reference: Oosterhoff, B. & Palmer, C.A. Attitudes and psychological factors associated with news monitoring, social … Continue reading How did adolescents view COVID-19 at the start of the pandemic, and how did their attitudes shape their associated behaviors?

Does treatment with colchicine lead to improved clinical outcomes in patients with severe COVID-19?

Bottom Line: Colchicine may slow disease progression in patients with severe COVID-19. Reference: Deftereos, S.G. et al. Effect of colchicine vs standard care on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019. JAMA Network Open (2020). https://doi.org/10.1001/jamanetworkopen.2020.13136 Date Published: 24 June 2020 Synopsis: Systemic inflammation plays a role in disease progression … Continue reading Does treatment with colchicine lead to improved clinical outcomes in patients with severe COVID-19?

What is the proportion of essential workers in the United States, and what proportion of essential workers live in households with higher-risk populations?

Bottom Line: 40% of workers in the United States were classified as essential workers, and 51% of households had at least 1 essential worker. Nearly half of essential workers lived in a household with moderate risk, while over 1 in 10 essential workers lived in higher-risk households. Reference: McCormack, G. et al. Economic vulnerability of households … Continue reading What is the proportion of essential workers in the United States, and what proportion of essential workers live in households with higher-risk populations?

What are the clinical effects of the anti-inflammatory medication tocilizumab on patients with COVID-19?

Bottom Line: The use tocilizumab was associated with lower mortality; however, tocilizumab did not show improvement in patients with severe to critical COVID-19. Reference: Rojas-Marte, G.R. et al. Outcomes in patients with severe COVID-19 disease treated with Tocilizumab – A case- Controlled study. QJM: An International Journal of Medicine (2020). https://doi.org/10.1093/qjmed/hcaa206 Date Published: 22 June 2020 Synopsis: The … Continue reading What are the clinical effects of the anti-inflammatory medication tocilizumab on patients with COVID-19?