Bottom Line: Few non-hospitalized patients infected with SARS-CoV-2 presented with asthma. Furthermore, the infection has not been found to be a significant contributor to asthma exacerbation. Reference: Garcia-Pachon E. et al. Asthma prevalence in patients with SARS-CoV-2 infection detected by RT-PCR not requiring hospitalization. Respir Med (2020). DOI: 10.1016/j.rmed.2020.106084 Date Published: 4 July 2020 Synopsis: … Continue reading What is the prevalence of asthma in patients who are not hospitalized with the SARS-CoV-2 infection?
Bottom Line: Only approximately 5% of the Spanish population has developed antibodies to SARS-CoV-2 after the initial epidemic wave. Reference: Pollán, M. et al. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. The Lancet (2020). https://doi.org/10.1016/s0140-6736(20)31483-5 Date Published: 6 July 2020 Synopsis: Spain was one of the European countries most affected by the … Continue reading What proportion of the population of Spain has developed antibodies to the SARS-CoV-2 infection?
Bottom Line: A public health campaign in the Netherlands using a widely-circulated news article with infographics and a video featuring a social media influencer led to increases in hand washing, greater awareness of face touching, and physical distancing. Reference: Yousuf, H. et al. Association of a public health campaign about coronavirus disease 2019 promoted by news … Continue reading Can public health campaigns help change behaviours that lead to reduced COVID-19 transmission?
Bottom Line: The slightly positively charged spike protein is thought to allow the virus to enter the central nervous system and cause a brain infection. Reference: Hassanzadeh, K. et al. Considerations around the SARS-Cov-2 spike protein with particular attention to COVID-19 brain infection and neurological symptoms. ACS Chemical Neuroscience (2020). https://doi.org/10.1021/acschemneuro.0c00373 Date Published: 6 July 2020 Synopsis: Increasing … Continue reading How is the SARS-CoV-2 virus able to invade the brain and cause an infection?
Bottom Line: From March 1 through to May 30, 2020 there were 120,000 more deaths than would have been expected based on previous years, with roughly 80% of these extra deaths being due to COVID-19 and 20% being due to causes other than COVID-19. Reference: Weinberger, D.M. et al. Estimation of excess deaths associated with the … Continue reading During the COVID-19 pandemic, have there been more deaths of any cause than would have been expected based on the death rate in previous years?
Bottom Line: Older age and medications called immune checkpoint inhibitors are associated with more severe COVID-19 infections in patients with cancer. Reference: Robilotti, E.V. et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med (2020). https://doi.org/10.1038/s41591-020-0979-0 Date Published: 24 June 2020 Synopsis: Previous studies have shown that patients with cancer have a higher risk of death … Continue reading What clinical characteristics of patients with cancer are associated with worse COVID-19 disease?
Bottom Line: The majority of adolescents did not practice physical distancing, but did practice disinfecting behaviors and followed COVID-related news. Those who viewed the virus as more severe were significantly more likely to follow the news, practice physical distancing, and disinfecting behaviors. Reference: Oosterhoff, B. & Palmer, C.A. Attitudes and psychological factors associated with news monitoring, social … Continue reading How did adolescents view COVID-19 at the start of the pandemic, and how did their attitudes shape their associated behaviors?
Bottom Line: Colchicine may slow disease progression in patients with severe COVID-19. Reference: Deftereos, S.G. et al. Effect of colchicine vs standard care on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019. JAMA Network Open (2020). https://doi.org/10.1001/jamanetworkopen.2020.13136 Date Published: 24 June 2020 Synopsis: Systemic inflammation plays a role in disease progression … Continue reading Does treatment with colchicine lead to improved clinical outcomes in patients with severe COVID-19?
Bottom Line: 40% of workers in the United States were classified as essential workers, and 51% of households had at least 1 essential worker. Nearly half of essential workers lived in a household with moderate risk, while over 1 in 10 essential workers lived in higher-risk households. Reference: McCormack, G. et al. Economic vulnerability of households … Continue reading What is the proportion of essential workers in the United States, and what proportion of essential workers live in households with higher-risk populations?
Bottom Line: The use tocilizumab was associated with lower mortality; however, tocilizumab did not show improvement in patients with severe to critical COVID-19. Reference: Rojas-Marte, G.R. et al. Outcomes in patients with severe COVID-19 disease treated with Tocilizumab – A case- Controlled study. QJM: An International Journal of Medicine (2020). https://doi.org/10.1093/qjmed/hcaa206 Date Published: 22 June 2020 Synopsis: The … Continue reading What are the clinical effects of the anti-inflammatory medication tocilizumab on patients with COVID-19?